Analytical Strategies for Oligonucleotide Conjugates: Overcoming Heterogeneity to Enable IND Readiness

• Addressing conjugation-driven heterogeneity and complexity in oligonucleotide conjugates to enable robust characterization and control
• Defining and controlling critical quality attributes (CQAs) such as DAR, linkage stability, and payload distribution to support IND readiness
• Designing scalable analytical strategies across internal teams and CDMOs to ensure consistent characterization through development and tech transfer

Speakers:

Ying Xu

Associate Director

Souffle Therapeutics