Roundtable Discussion: What Constitutes Chemical Consistency in Novel Conjugated Oligonucleotides?
- When heterogeneity is inherent, how is “chemical consistency” realistically defined for AOCs and conjugated oligonucleotides?
- Beyond OAR, what additional structural, positional, and linker-level controls are necessary to demonstrate reproducibility?
- How should long and highly modified oligo constructs be characterized to prove structural integrity?