Roundtable Discussion: What Constitutes Chemical Consistency in Novel Conjugated Oligonucleotides?

• When heterogeneity is inherent, how is “chemical consistency” realistically defined for AOCs and conjugated oligonucleotides?
• Beyond OAR, what additional structural, positional, and linker-level controls are necessary to demonstrate reproducibility?
• How should long and highly modified oligo constructs be characterized to prove structural integrity?

Speakers:

Kok Seong Lim

Independent Cell & Gene Therapy CMC Expert

Independent Expert