Fireside Chat: Evaluating Solid-Phase, Enzymatic, & Liquid-Phase Synthesis Routes to Enable Scalable & Sustainable Oligonucleotide Production
- Comparing yield efficiency, impurity formation profiles, and sequence-length constraints across different phase oligo platforms
- Assessing platform readiness for GMP control, stereochemical management, and regulatory acceptance when introducing alternative synthesis technologies
- Determining when transitioning synthesis routes materially improves long-term scalability and manufacturing flexibility