Pre-Conference Workshop - Monday August 25, 2025

8:00 am Check-In

9:00 am Workshop A: Analytical Development Techniques and Challenges for Highly Modified Oligonucleotides

Synopsis

This workshop will explore advanced analytical methods and considerations for 

addressing the unique challenges posed by complex oligonucleotide subtypes. With 

a focus on overcoming hurdles in their analytical development, with specificity to 

analytics of quantification, characterization, impurity profiling, and complex delivery 

routes.

Highlights of this workshop include:

• Deep dive into analytics for oligos and oligoconjugates including quantification, 

characterization, and impurity profiling

• Discussions of analytical techniques supporting phosphonodiamidite morpholino 

oligonucleotide and oligonucleotide-conjugate manufacturing

• Modifications to regulatory submission packages for these novel or complex oligo 

modalities

• Overcoming challenges in analytics for complex delivery methods such as LNPs 

and targeting to specific tissues

12:00 pm End of Pre-Conference Workshop Day