Pre-Conference Workshop - Monday August 25, 2025

8:00 am Check-In

9:00 am Workshop A: Analytical Development Techniques and Challenges for Highly Modified Oligonucleotides

  • Hongling Han Senior Director, Head of Analytical Development & QC, PepGen
  • Kok-Seong Lim Senior Director, Analytical Sciences & Quality Control, Independent Expert

Synopsis

This workshop will explore advanced analytical methods and considerations for  addressing the unique challenges posed by complex oligonucleotide subtypes. With  a focus on overcoming hurdles in their analytical development, with specificity to  analytics of quantification, characterization, impurity profiling, and complex delivery routes.

Highlights of this workshop include:

  • Deep dive into analytics for oligos and oligoconjugates including quantification, characterization, and impurity profiling
  • Discussions of analytical techniques supporting phosphonodiamidite morpholino  oligonucleotide and oligonucleotide-conjugate manufacturing
  • Modifications to regulatory submission packages for these novel or complex oligo modalities
  • Overcoming challenges in analytics for complex delivery methods such as LNPs and targeting to specific tissues

12:00 pm End of Pre-Conference Workshop Day

Full Event Guide
Day One