Rapid, Automated Residence Time Distribution (RTD) Modeling for SolidPhase Oligonucleotide Synthesis (SPOS) using Process Data
Time: 2:30 pm
day: Day Two PM
Details:
• Using the column inlet and outlet conductivity signals during coupling can provide
information about flow through the column during each cycle without the need for
interrupting the synthesis
• RTD modeling and fitting can be automated and performed in seconds, with potential for
real-time implementation
• This approach involves some drawbacks which limit applicability somewhat
• Syntheses can be compared to assess the interdependencies of process equipment/
materials/conditions, flow character, and analytical results
