Methods for Establishment of Stereochemical Comparability in Phosphorothioated Oligos: Analytical Approaches & Development Strategies
Time: 9:00 am
day: Day Two AM
Details:
• Designing ASO sequences with different stereochemical content
• Evaluation of three analytical methods CD, NMR, and NP1/LCMS for assessing
stereochemistry
• Developing a robust comparability criteria and strategy based on analytical outputs to
assess and control stereochemistry across batches
