Continuous Process Improvement: Limitations of an Early-Stage Manufacturing Process Addressed By Innovative Chemistry
Time: 4:00 pm
day: Day One PM
Details:
• Due to some unique structural characteristics, appropriate process parameters were
developed for the first GMP delivery
• Cleavage and Deprotection conditions were carefully designed to generate material
meeting desired specifications
• A deeper understanding of the chemical process led to development of a robust protocol
that is amenable to large-scale synthesis using typical oligo plant equipment
