Bridging Early Analytical Development & GMP Manufacturing: Implementing Scalable Control Strategies for Oligonucleotides

  • Establishing early-phase impurity characterization and analytical strategies to inform downstream manufacturing control decisions
  • Translating analytical methods into GMP-ready assays to ensure consistency, robustness, and regulatory compliance in manufacturing environments
  • Addressing common disconnects between development and manufacturing teams to enable effective tech transfer and reduce scale-up risk