AEX & IPRP Orthogonal Method Explorations for Critical Impurity Profiling of Late-Stage siRNA Oligonucleotides
Time: 11:00 am
day: Day One AM
Details:
• Development and optimization of Anion Exchange Chromatography (AEX) and Ion Pair
Reversed phase (IPRP) methods for profiling critical impurities in oligos
• Instrumentation considerations and procedural harmonization to support robust,
reproducible methods for quality control release and stability testing under stringent
regulatory requirements
• Targeted strategies for method corrections and refinements of AEX and IPRP
techniques for siRNAs to ensure accurate impurity detection
