Advancing Characterization & Control of Stereochemical Complexity in ASO’s to Enable Consistent Quality, Efficacy, & Regulatory Confidence
- Establishing robust analytical strategies to resolve and characterize stereoisomeric heterogeneity to ensure batch consistency and strengthen structure–activity understanding
- Leveraging orthogonal characterization techniques to decode phosphorothioate stereochemistry to de-risk impurity profiles and inform control strategy development
- Defining stage-appropriate stereochemical specifications based on characterization data to align with regulatory expectations and enable scalable, reproducible manufacturing