Analytical Strategies for Oligonucleotide Impurity Monitoring & Control in Oligonucleotide Conjugates
Time: 2:00 pm
day: Day One PM
Details:
- Exploring the key challenges in the characterization and control of oligonucleotide protein transport vehicle (OTV) conjugates
- These challenges include the masking of protein charge variant profiles by the highly negative charge of the oligonucleotide and the fate and criticality of oligonucleotide impurities during conjugation
- Additionally, the unique considerations for residual payload assays compared to antibody-small molecule drug conjugates. Strategies for addressing these issues will be discussed
