Advanced Analytical Solutions for Complex Oligos Modalities to Ensure Quality & Expedite Development
Time: 1:30 pm
day: Day One PM
Details:
Analytical Strategies for Oligonucleotide Impurity Monitoring & Control in
Oligonucleotide Conjugates
• A series of vignettes for approaches to monitoring oligonucleotides critical quality
attributes in oligonucleotide conjugates
• Monitoring of impurity identity and quantities in OTVs with LC-MS
• Use of 31P NMR for orthogonal impurity detection, assay and impurity identification
• Use of 31P NMR for monitoring diastereomer ratios
